Bioconjugation and stabilisation of biomolecules in biosensors.   
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Bioconjugation and stabilisation of biomolecules in biosensors.

Essays Biochem. 2016 Jun 30;60(1):59-68

Authors: Liébana S, Drago GA

Abstract
Suitable bioconjugation strategies and stabilisation of biomolecules on electrodes is essential for the development of novel and commercially viable biosensors. In the present review, the functional groups that comprise the selectable targets for practical bioconjugation methods are discussed. We focus on describing the most common immobilisation techniques used in biosensor construction, which are classified into irreversible and reversible methods. Concerning the stability of proteins, the two main types of stability may be defined as (i) storage or shelf stability, and (ii) operational stability. Both types of stability are explained, as well as the introduction of an electrophoretic technique for predicting protein-polymer interactions. In addition, solution and dry stabilisation as well as stabilisation using the covalent immobilisation of proteins are discussed including possible factors that influence stability. Finally, the integration of nanomaterials, such as magnetic particles, with protein immobilisation is discussed in relation to protein stability studies.

PMID: 27365036 [PubMed - indexed for MEDLINE]


          Introduction to biosensors.   
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Introduction to biosensors.

Essays Biochem. 2016 Jun 30;60(1):1-8

Authors: Bhalla N, Jolly P, Formisano N, Estrela P

Abstract
Biosensors are nowadays ubiquitous in biomedical diagnosis as well as a wide range of other areas such as point-of-care monitoring of treatment and disease progression, environmental monitoring, food control, drug discovery, forensics and biomedical research. A wide range of techniques can be used for the development of biosensors. Their coupling with high-affinity biomolecules allows the sensitive and selective detection of a range of analytes. We give a general introduction to biosensors and biosensing technologies, including a brief historical overview, introducing key developments in the field and illustrating the breadth of biomolecular sensing strategies and the expansion of nanotechnological approaches that are now available.

PMID: 27365030 [PubMed - indexed for MEDLINE]


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          A review on symptoms, treatments protocols and proteomic profile in sulfur mustard-exposed victims - Abdolghaffari AH, Panahi Y, Sahebkar A.    
Sulfur mustard (SM) as an alkylating and vesicating agent was used for 100 years as a chemical weapon. SM as bi-functional mustard can attacks and alkylates lots of biomolecules. Different cellular mechanism and molecular pathways are responsible for damag...
          A review on symptoms, treatments protocols and proteomic profile in sulfur mustard-exposed victims - Abdolghaffari AH, Panahi Y, Sahebkar A.    
Sulfur mustard (SM) as an alkylating and vesicating agent was used for 100 years as a chemical weapon. SM as bi-functional mustard can attacks and alkylates lots of biomolecules. Different cellular mechanism and molecular pathways are responsible for damag...
          IPUCET 2017   
Respected Seniors. I am an aspirant for CET (131) 2017.

Can you help me with my coming exam? What I've done is

Physics:-
XI Complete (CBSE Level only)
XII Complete (CBSE Level only)

Chemistry:-

XI => Some Basic Concepts of Chemistry, Structure of Atom, Classification of Elements and their properties, Chemical Bonding and Molecular Structure, States of Matter, Thermodynamics, Equilibrium (Only Chemical), Redox Reactions, Hydrogen

XII => Solid State, Solutions, Electrochemistry, Chemical Kinetics, Surface Chemistry, General Properties and Isolation of Elements, Coordination Compounds, Haloalkanes and Haloarenes, Polymers, Biomolecules, Chemistry in Everyday life.

Whole Organic Left. S, P, D, F Blocks left.

Maths:-
XII (CBSE Level) excluding Probability. Also, weak in Integration.

XI => Trigonometry, Straight Lines, Binomial Theorem, Sets, Relations, Mathematical Logic and Reasoning.

So, my question is how many marks can I score in each of them according to what I've prepared?
And, if my following guess is right?
P - 25 correct
C - 15 correct
M - 10 or above correct
Total - 50 or above (200+)
I need to get a rank between 10,000 and 15,000. So, please also suggest if I am right in aiming for above 200 marks in the exam.